GrippeCanadaV3, Main, Exploration, bibRecord, 000045

Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009-2011.

Identifieur interne : 000045 ( Main/Exploration ); précédent : 000044; suivant : 000046

Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009-2011.

Auteurs : Melissa A. Rolfes [Géorgie (pays)] ; F Liaini Gross [Géorgie (pays)] ; Brendan Flannery [Géorgie (pays)] ; Adrienne F A. Meyers [Kenya] ; Ma Luo ; Nathalie Bastien ; Robert A. Fowler [Canada] ; Jacqueline M. Katz [Géorgie (pays)] ; Min Z. Levine [Géorgie (pays)] ; Anand Kumar [Canada] ; Timothy M. Uyeki [Géorgie (pays)]

Source :

The Journal of infectious diseases [ 1537-6613 ] ; 2018.

RBID : pubmed:29342251

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Canada (épidémiologie), Facteurs de risque, Facteurs temps, Femelle, Grippe humaine (mortalité), Grippe humaine (sang), Grippe humaine (épidémiologie), Humains, Jeune adulte, Maladie grave, Mâle, Pandémies, Saisons, Sous-type H1N1 du virus de la grippe A (immunologie), Sujet âgé.
MESH :
- immunologie : Sous-type H1N1 du virus de la grippe A.
- mortalité : Grippe humaine.
- sang : Anticorps antiviraux, Grippe humaine.
- épidémiologie : Canada, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs de risque, Facteurs temps, Femelle, Humains, Jeune adulte, Maladie grave, Mâle, Pandémies, Saisons, Sujet âgé.
Wicri :
- geographic : Canada.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Antibodies, Viral (blood), Canada (epidemiology), Critical Illness, Female, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza, Human (blood), Influenza, Human (epidemiology), Influenza, Human (mortality), Male, Middle Aged, Pandemics, Risk Factors, Seasons, Time Factors, Young Adult.
MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Canada.
- blood : Influenza, Human.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype.
- mortality : Influenza, Human.
- Adolescent, Adult, Aged, Critical Illness, Female, Humans, Male, Middle Aged, Pandemics, Risk Factors, Seasons, Time Factors, Young Adult.

Abstract

Background

The kinetics of the antibody response during severe influenza are not well documented.

Methods

Critically ill patients infected with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), confirmed by reverse-transcription polymerase chain reaction analysis or seroconversion (defined as a ≥4-fold rise in titers), during 2009-2011 in Canada were prospectively studied. Antibody titers in serially collected sera were determined using hemagglutinin inhibition (HAI) and microneutralization assays. Average antibody curves were estimated using linear mixed-effects models and compared by patient outcome, age, and corticosteroid treatment.

Results

Of 47 patients with A(H1N1)pdm09 virus infection (median age, 47 years), 59% had baseline HAI titers of <40, and 68% had baseline neutralizing titers of <40. Antibody titers rose quickly after symptom onset, and, by day 14, 83% of patients had HAI titers of ≥40, and 80% had neutralizing titers ≥40. Baseline HAI titers were significantly higher in patients who died compared with patients who survived; however, the antibody kinetics were similar by patient outcome and corticosteroid treatment. Geometric mean titers over time in older patients were lower than those in younger patients.

Conclusions

Critically ill patients with influenza A(H1N1)pdm09 virus infection had strong HAI and neutralizing antibody responses during their illness. Antibody kinetics differed by age but were not associated with patient outcome.

DOI: 10.1093/infdis/jiy013
PubMed: 29342251

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M" last="Uyeki">Timothy M. Uyeki</name>
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<series><title level="j">The Journal of infectious diseases</title>
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<term>Adult</term>
<term>Aged</term>
<term>Antibodies, Viral (blood)</term>
<term>Canada (epidemiology)</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza, Human (blood)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (mortality)</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Seasons</term>
<term>Time Factors</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Canada (épidémiologie)</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (sang)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Saisons</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sujet âgé</term>
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<term>Grippe humaine</term>
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<term>Grippe humaine</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Critical Illness</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Risk Factors</term>
<term>Seasons</term>
<term>Time Factors</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Maladie grave</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Saisons</term>
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<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>The kinetics of the antibody response during severe influenza are not well documented.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Methods</b>
</p>
<p>Critically ill patients infected with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), confirmed by reverse-transcription polymerase chain reaction analysis or seroconversion (defined as a ≥4-fold rise in titers), during 2009-2011 in Canada were prospectively studied. Antibody titers in serially collected sera were determined using hemagglutinin inhibition (HAI) and microneutralization assays. Average antibody curves were estimated using linear mixed-effects models and compared by patient outcome, age, and corticosteroid treatment.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>Of 47 patients with A(H1N1)pdm09 virus infection (median age, 47 years), 59% had baseline HAI titers of <40, and 68% had baseline neutralizing titers of <40. Antibody titers rose quickly after symptom onset, and, by day 14, 83% of patients had HAI titers of ≥40, and 80% had neutralizing titers ≥40. Baseline HAI titers were significantly higher in patients who died compared with patients who survived; however, the antibody kinetics were similar by patient outcome and corticosteroid treatment. Geometric mean titers over time in older patients were lower than those in younger patients.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusions</b>
</p>
<p>Critically ill patients with influenza A(H1N1)pdm09 virus infection had strong HAI and neutralizing antibody responses during their illness. Antibody kinetics differed by age but were not associated with patient outcome.</p>
</div>
</front>
</TEI>
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<DateCompleted><Year>2019</Year>
<Month>07</Month>
<Day>10</Day>
</DateCompleted>
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<Month>10</Month>
<Day>08</Day>
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<JournalIssue CitedMedium="Internet"><Volume>217</Volume>
<Issue>7</Issue>
<PubDate><Year>2018</Year>
<Month>03</Month>
<Day>13</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
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<ArticleTitle>Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009-2011.</ArticleTitle>
<Pagination><MedlinePgn>1078-1088</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/infdis/jiy013</ELocationID>
<Abstract><AbstractText Label="Background">The kinetics of the antibody response during severe influenza are not well documented.</AbstractText>
<AbstractText Label="Methods">Critically ill patients infected with 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09), confirmed by reverse-transcription polymerase chain reaction analysis or seroconversion (defined as a ≥4-fold rise in titers), during 2009-2011 in Canada were prospectively studied. Antibody titers in serially collected sera were determined using hemagglutinin inhibition (HAI) and microneutralization assays. Average antibody curves were estimated using linear mixed-effects models and compared by patient outcome, age, and corticosteroid treatment.</AbstractText>
<AbstractText Label="Results">Of 47 patients with A(H1N1)pdm09 virus infection (median age, 47 years), 59% had baseline HAI titers of <40, and 68% had baseline neutralizing titers of <40. Antibody titers rose quickly after symptom onset, and, by day 14, 83% of patients had HAI titers of ≥40, and 80% had neutralizing titers ≥40. Baseline HAI titers were significantly higher in patients who died compared with patients who survived; however, the antibody kinetics were similar by patient outcome and corticosteroid treatment. Geometric mean titers over time in older patients were lower than those in younger patients.</AbstractText>
<AbstractText Label="Conclusions">Critically ill patients with influenza A(H1N1)pdm09 virus infection had strong HAI and neutralizing antibody responses during their illness. Antibody kinetics differed by age but were not associated with patient outcome.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rolfes</LastName>
<ForeName>Melissa A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation>
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</AffiliationInfo>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Microbiology and Infectious Diseases, Winnipeg.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Microbiology, University of Nairobi, Kenya.</Affiliation>
</AffiliationInfo>
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<Initials>M</Initials>
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</AffiliationInfo>
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<ForeName>Nathalie</ForeName>
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<Initials>JM</Initials>
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</AffiliationInfo>
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<ForeName>Min Z</ForeName>
<Initials>MZ</Initials>
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</AffiliationInfo>
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<ForeName>Anand</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Section of Critical Care Medicine, Winnipeg.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Section of Infectious Diseases, University of Manitoba, Winnipeg.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Timothy M</ForeName>
<Initials>TM</Initials>
<AffiliationInfo><Affiliation>Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>CSIS and ROSII Study Groups</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
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<Agency>Intramural CDC HHS</Agency>
<Country>United States</Country>
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<MedlineTA>J Infect Dis</MedlineTA>
<NlmUniqueID>0413675</NlmUniqueID>
<ISSNLinking>0022-1899</ISSNLinking>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009-2011.

Kinetics of Serological Responses in Critically Ill Patients Hospitalized With 2009 Pandemic Influenza A(H1N1) Virus Infection in Canada, 2009-2011.

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